![]() ![]() ![]() To gauge whether heart patients treated with ACE inhibitors might face increased risk of infection during heart valve replacement or repair, Khan and colleagues tested laboratory mice under conditions that mimic heart surgery, exposing them to methicillin-resistant Staphylococcus aureus (MRSA), a drug-resistant type of bacteria. ACE inhibitors block production of the hormone and lower blood pressure by allowing veins and arteries to relax. "ACE inhibitors are good medicines, but we wanted to further explore this association because alternative drugs are now available."Īngiotensin-converting enzyme (ACE) increases blood pressure by producing the hormone angiotensin II, which constricts blood vessels. " While these drugs have been largely thought to be safe, published studies have noted an association between the use of ACE inhibitors and some forms of infection," said Zakir Khan, PhD, assistant professor of Research in the departments of Biomedical Sciences and Pathology and Laboratory Medicine at Cedars-Sinai and senior author of the study. The study was published July 29 in Science Translational Medicine. ACE inhibitors, a type of medication taken daily by millions of Americans to treat hypertension, diabetic kidney disease and heart failure, could increase patents' risk of infection under certain conditions, preliminary research from Cedars-Sinai suggests.Īlthough further study is needed, the finding eventually could lead healthcare providers to prescribe alternatives for some patients. ![]()
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